TPP2 Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Stimulates adipogenesis. Belongs to the peptidase S8 family. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.14.10; Protease
Chromosomal Location of Human Ortholog: 13q33.1
Cellular Component:  cytoplasm; cytosol; nuclear body; nucleoplasm
Molecular Function:  aminopeptidase activity; endopeptidase activity; identical protein binding; protein binding; serine-type endopeptidase activity
Biological Process:  protein polyubiquitination; proteolysis
Disease: Immunodeficiency 78 With Autoimmunity And Developmental Delay
Reference #:  P29144 (UniProtKB)
Alt. Names/Synonyms: FLJ40359; TPP-2; TPP-II; TPP2; TPPII; Tripeptidyl aminopeptidase; tripeptidyl peptidase 2; tripeptidyl peptidase II; Tripeptidyl-peptidase 2; Tripeptidyl-peptidase II
Gene Symbols: TPP2
Molecular weight: 138,350 Da
Basal Isoelectric point: 5.9  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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TPP2

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene