TPP2
Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Stimulates adipogenesis. Belongs to the peptidase S8 family. Note: This description may include information from UniProtKB.
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Protein type: EC 3.4.14.10; Protease |
Chromosomal Location of human Ortholog: 13q33.1 |
Cellular Component:
cytoplasm; cytosol; nuclear body; nucleoplasm
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Molecular Function:
aminopeptidase activity; endopeptidase activity; identical protein binding; protein binding; serine-type endopeptidase activity; tripeptidyl-peptidase activity
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Biological Process:
intracellular amino acid homeostasis; protein polyubiquitination; proteolysis
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Disease: Immunodeficiency 78 With Autoimmunity And Developmental Delay
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Reference #:
P29144
(UniProtKB)
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Alt. Names/Synonyms: FLJ40359; TPP-2; TPP-II; TPP2; TPPII; Tripeptidyl aminopeptidase; tripeptidyl peptidase 2; tripeptidyl peptidase II; Tripeptidyl-peptidase 2; Tripeptidyl-peptidase II
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Gene Symbols: TPP2
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Molecular weight:
138,350 Da
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Basal Isoelectric point:
5.9
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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