RHBDL6 Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. Belongs to the peptidase S54 family. Found in the epidermis and esophageal epithelium. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of mouse Ortholog: 11|11 E2
Cellular Component:  endoplasmic reticulum; endoplasmic reticulum membrane; integral component of membrane; membrane; plasma membrane
Molecular Function:  protein binding
Biological Process:  negative regulation of protein secretion; protein transport; proteolysis; regulation of epidermal growth factor receptor signaling pathway; regulation of protein secretion
Reference #:  Q80WQ6 (UniProtKB)
Alt. Names/Synonyms: 4732465I17Rik; cub; Inactive rhomboid protein 2; iRh; Irhom2; OTTMUSP00000004272; OTTMUSP00000004274; Rhbd; Rhbdf2; Rhbdl6; RHDF2; rhomboid 5 homolog 2; rhomboid 5 homolog 2 (Drosophila); Rhomboid family member 2; Rhomboid veinlet-like protein 6; rhomboid, veinlet-like 6; rhomboid-like protein 6; Rhomboid-related protein; Rhor
Gene Symbols: Rhbdf2
Molecular weight: 93,434 Da
Basal Isoelectric point: 9.05  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene