RHBDL6 Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. Belongs to the peptidase S54 family. Found in the epidermis and esophageal epithelium. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of human Ortholog: 17q25.1
Cellular Component:  endoplasmic reticulum membrane; Golgi lumen; plasma membrane
Molecular Function:  growth factor binding; protein binding; protein transporter activity; serine-type endopeptidase activity
Biological Process:  negative regulation of inflammatory response to antigenic stimulus; negative regulation of protein secretion; protein localization to plasma membrane; protein transport; regulation of epidermal growth factor receptor signaling pathway; regulation of metalloendopeptidase activity; regulation of protein secretion
Disease: Tylosis With Esophageal Cancer
Reference #:  Q6PJF5 (UniProtKB)
Alt. Names/Synonyms: FLJ22341; Inactive rhomboid protein 2; IRHOM2; RHBDF2; RHBDL5; RHBDL6; RHDF2; Rhomboid 5 homolog 2; rhomboid 5 homolog 2 (Drosophila); Rhomboid family member 2; rhomboid veinlet-like 5; Rhomboid veinlet-like protein 5; Rhomboid veinlet-like protein 6; rhomboid, veinlet-like 6; rhomboid-like protein 6; TEC; TOC; TOCG
Gene Symbols: RHBDF2
Molecular weight: 96,686 Da
Basal Isoelectric point: 9.1  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein