K14 The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. Belongs to the intermediate filament family. Detected in the basal layer, lowered within the more apically located layers specifically in the stratum spinosum, stratum granulosum but is not detected in stratum corneum. Strongly expressed in the outer root sheath of anagen follicles but not in the germinative matrix, inner root sheath or hair. Found in keratinocytes surrounding the club hair during telogen. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of mouse Ortholog: 11 63.43 cM|11 D
Cellular Component:  basal part of cell; cell periphery; cornified envelope; cytoplasm; cytoskeleton; intermediate filament; intracellular anatomical structure; keratin filament; nucleus
Molecular Function:  keratin filament binding; protein binding; structural molecule activity
Biological Process:  epithelial cell differentiation; hair cycle; intermediate filament bundle assembly; intermediate filament organization; keratinocyte differentiation; stem cell differentiation
Reference #:  Q61781 (UniProtKB)
Alt. Names/Synonyms: AI626930; CK-14; cytokeratin 14; Cytokeratin-14; epidermolysis bullosa simplex, Dowling-Meara, Koebner; K14; K1C14; keratin 14; keratin complex 1, acidic, gene 14; Keratin, type I cytoskeletal 14; Keratin-14; Krt-1.1; Krt-1.14; Krt1-1; Krt1-14; Krt14; OTTMUSP00000002389
Gene Symbols: Krt14
Molecular weight: 52,867 Da
Basal Isoelectric point: 5.1  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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K14

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein