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DCHS1
Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation. In the heart, has a critical role for proper morphogenesis of the mitral valve, acting in the regulation of cell migration involved in valve formation. Expressed in fibroblasts but not in melanocytes or keratinocytes. Note: This description may include information from UniProtKB.
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| Protein type: Cell adhesion; Membrane protein, integral |
| Chromosomal Location of Human Ortholog: 7|7 E3 |
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Cellular Component:
apical part of cell; integral component of membrane; membrane; plasma membrane
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Molecular Function:
calcium ion binding
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Biological Process:
anatomical structure morphogenesis; branching involved in ureteric bud morphogenesis; cell adhesion; cell migration; cell migration involved in endocardial cushion formation; cell-cell adhesion; cochlea development; condensed mesenchymal cell proliferation; digestive tract development; establishment of planar polarity; heart morphogenesis; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; hippo signaling; homophilic cell adhesion via plasma membrane adhesion molecules; kidney development; mitral valve formation; mitral valve morphogenesis; nephron development; neural tube development; neurogenesis; ossification involved in bone maturation; pattern specification process; post-anal tail morphogenesis; protein localization to plasma membrane
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Reference #:
E9PVD3
(UniProtKB)
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Alt. Names/Synonyms: 3110041P15Rik; C130033F22Rik; CDH25; dachsous 1; dachsous cadherin related 1; Dchs1; FIB1; Gm165; PCD16; PCDH16; Protein dachsous homolog 1; Protein Dchs1; Protocadherin-16
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Gene Symbols: Dchs1
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Molecular weight:
346,384 Da
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Basal Isoelectric point:
4.83
Predict pI for various phosphorylation states
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CST Pathways:
Hippo Signaling
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