DCHS1 Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation. In the heart, has a critical role for proper morphogenesis of the mitral valve, acting in the regulation of cell migration involved in valve formation. Expressed in fibroblasts but not in melanocytes or keratinocytes. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7|7 E3
Cellular Component:  apical part of cell; integral component of membrane; membrane; plasma membrane
Molecular Function:  calcium ion binding
Biological Process:  anatomical structure morphogenesis; branching involved in ureteric bud morphogenesis; cell adhesion; cell migration; cell migration involved in endocardial cushion formation; cell-cell adhesion; cochlea development; condensed mesenchymal cell proliferation; digestive tract development; establishment of planar polarity; heart morphogenesis; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; hippo signaling; homophilic cell adhesion via plasma membrane adhesion molecules; kidney development; mitral valve formation; mitral valve morphogenesis; nephron development; neural tube development; neurogenesis; ossification involved in bone maturation; pattern specification process; post-anal tail morphogenesis; protein localization to plasma membrane
Reference #:  E9PVD3 (UniProtKB)
Alt. Names/Synonyms: 3110041P15Rik; C130033F22Rik; CDH25; dachsous 1; dachsous cadherin related 1; Dchs1; FIB1; Gm165; PCD16; PCDH16; Protein dachsous homolog 1; Protein Dchs1; Protocadherin-16
Gene Symbols: Dchs1
Molecular weight: 346,384 Da
Basal Isoelectric point: 4.83  Predict pI for various phosphorylation states
CST Pathways:  Hippo Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  BioGPS  |  Pfam  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein