PFKM Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade E sub-subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC; Kinase, other
Chromosomal Location of Human Ortholog: 15|15 F1
Cellular Component:  6-phosphofructokinase complex; apical plasma membrane; cell projection; cilium; cytoplasm; cytosol; membrane; motile cilium; nucleus; sperm principal piece
Molecular Function:  6-phosphofructokinase activity; AMP binding; ATP binding; carbohydrate binding; catalytic activity; fructose binding; fructose-6-phosphate binding; identical protein binding; kinase activity; kinase binding; metal ion binding; monosaccharide binding; nucleotide binding; phosphofructokinase activity; protein binding; protein C-terminus binding; protein homodimerization activity; transferase activity
Biological Process:  canonical glycolysis; fructose 1,6-bisphosphate metabolic process; fructose 6-phosphate metabolic process; glucose catabolic process; glucose homeostasis; glycogen catabolic process; glycolysis from storage polysaccharide through glucose-1-phosphate; glycolytic process; glycolytic process through fructose-6-phosphate; metabolic process; muscle cell cellular homeostasis; phosphorylation; positive regulation of insulin secretion; positive regulation of transcription by RNA polymerase II; protein complex oligomerization; protein homotetramerization
Reference #:  P47857 (UniProtKB)
Alt. Names/Synonyms: 6-phosphofructokinase, muscle type; AI131669; ATP-dependent 6-phosphofructokinase, muscle type; K6PF; Pfk-4; PFK-A; Pfk-m; Pfk4; Pfka; Pfkm; Pfkx; Phosphofructo-1-kinase isozyme A; Phosphofructokinase 1; phosphofructokinase 4; phosphofructokinase, muscle; phosphofructokinase, polypeptide X; phosphofructokinase-1 A isozyme; Phosphofructokinase-M; phosphofructokinase-M (connecting peptide); Phosphohexokinase
Gene Symbols: Pfkm
Molecular weight: 85,269 Da
Basal Isoelectric point: 8.24  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene