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PFKM
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade E sub-subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.1.11; Kinase, other |
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Cellular Component:
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Reference #:
P00511
(UniProtKB)
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Alt. Names/Synonyms: ATP-dependent 6-phosphofructokinase, muscle type; K6PF; PFK-A; PFKM; Phosphofructo-1-kinase isozyme A; Phosphofructokinase 1; phosphofructokinase, muscle; Phosphofructokinase-M; Phosphohexokinase
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Gene Symbols: PFKM
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Molecular weight:
85,203 Da
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Basal Isoelectric point:
8.48
Predict pI for various phosphorylation states
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CST Pathways:
Warburg Effect
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