PFKM Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade E sub-subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.1.11; Kinase, other
Cellular Component: 
Reference #:  P00511 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent 6-phosphofructokinase, muscle type; K6PF; PFK-A; PFKM; Phosphofructo-1-kinase isozyme A; Phosphofructokinase 1; phosphofructokinase, muscle; Phosphofructokinase-M; Phosphohexokinase
Gene Symbols: PFKM
Molecular weight: 85,203 Da
Basal Isoelectric point: 8.48  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
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PFKM

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene