ABCB4 a transporter that mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes ATP with low efficiency. Human ABCB4 is not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte. Interacts with HAX1. Defects are the cause of gallstones, and progressive familial intrahepatic cholestasis 3, an autosomal recessive liver disorder that progresses to cirrhosis and liver failure before adulthood. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family
Chromosomal Location of Human Ortholog: 5 A1|5 3.43 cM
Cellular Component:  actin cytoskeleton; apical plasma membrane; cytoplasm; cytoplasmic vesicle; cytosol; focal adhesion; Golgi membrane; integral component of membrane; intercellular canaliculus; membrane; nucleoplasm; plasma membrane
Molecular Function:  ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances; nucleotide binding; phosphatidylcholine transporter activity; phosphatidylcholine-translocating ATPase activity
Biological Process:  bile acid secretion; cellular response to bile acid; lipid homeostasis; lipid transport; phospholipid translocation; positive regulation of cholesterol transport; positive regulation of phospholipid translocation; positive regulation of phospholipid transport; response to fenofibrate; transmembrane transport
Reference #:  P21440 (UniProtKB)
Alt. Names/Synonyms: Abcb4; ATP-binding cassette sub-family B member 4; ATP-binding cassette, sub-family B (MDR/TAP), member 4; mdr-2; Mdr2; Multidrug resistance protein 2; P glycoprotein 2; P-glycoprotein 2; Pgy-2; Pgy2; Phosphatidylcholine translocator ABCB4
Gene Symbols: Abcb4
Molecular weight: 140,377 Da
Basal Isoelectric point: 8.88  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene