DEGS1 Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine). Belongs to the fatty acid desaturase family. DEGS subfamily. Note: This description may include information from UniProtKB.
Protein type: EC 1.14.-.-; Lipid Metabolism - sphingolipid; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase
Chromosomal Location of Human Ortholog: 1q42.11
Cellular Component:  endoplasmic reticulum; endoplasmic reticulum membrane; integral component of plasma membrane; membrane; mitochondrion; plasma membrane
Molecular Function:  electron transfer activity; sphingolipid delta-4 desaturase activity
Biological Process:  ceramide biosynthetic process; neutrophil degranulation; sphingolipid biosynthetic process; unsaturated fatty acid biosynthetic process
Reference #:  O15121 (UniProtKB)
Alt. Names/Synonyms: Cell migration-inducing gene 15 protein; Degenerative spermatocyte homolog 1; degenerative spermatocyte homolog 1, lipid desaturase (Drosophila); degenerative spermatocyte homolog, lipid desaturase; DEGS; DEGS1; Des-1; DES1; dihydroceramide desaturase; FADS7; membrane fatty acid (lipid) desaturase; Membrane lipid desaturase; MGC5079; MIG15; migration-inducing gene 15 protein; MLD; sphingolipid delta 4 desaturase; Sphingolipid delta(4)-desaturase DES1
Gene Symbols: DEGS1
Molecular weight: 37,866 Da
Basal Isoelectric point: 6.97  Predict pI for various phosphorylation states
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DEGS1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene