DEGS1 Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine). Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. Ubiquitous. Note: This description may include information from UniProtKB.
Protein type: EC 1.14.-.-; Lipid Metabolism - sphingolipid; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase
Chromosomal Location of Human Ortholog: 1|1 H5
Cellular Component:  endoplasmic reticulum; integral component of membrane; membrane; mitochondrion
Molecular Function:  oxidoreductase activity; sphingolipid delta-4 desaturase activity
Biological Process:  ceramide biosynthetic process; fatty acid biosynthetic process; fatty acid metabolic process; lipid metabolic process; oxidation-reduction process; positive regulation of apoptotic process; sphingolipid biosynthetic process
Reference #:  O09005 (UniProtKB)
Alt. Names/Synonyms: AA536663; Degenerative spermatocyte homolog 1; degenerative spermatocyte homolog 1 (Drosophila); Degs; Degs1; delta(4)-desaturase, sphingolipid 1; Des; Des1; dihydroceramide desaturase; Dihydroceramide desaturase-1; Mde; Mdes; OTTMUSP00000024135; Sphingolipid delta(4)-desaturase DES1
Gene Symbols: Degs1
Molecular weight: 38,241 Da
Basal Isoelectric point: 7.33  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene