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DEGS1
Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine). Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. Ubiquitous. Note: This description may include information from UniProtKB.
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| Protein type: EC 1.14.-.-; Lipid Metabolism - sphingolipid; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase |
| Chromosomal Location of mouse Ortholog: 1|1 H5 |
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Cellular Component:
endoplasmic reticulum; membrane; mitochondrion
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Molecular Function:
isomerase activity; oxidoreductase activity; retinol isomerase activity; sphingolipid delta-4 desaturase activity
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Biological Process:
ceramide biosynthetic process; fatty acid biosynthetic process; fatty acid metabolic process; lipid metabolic process; myelin maintenance; positive regulation of apoptotic process; sphingolipid biosynthetic process
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Reference #:
O09005
(UniProtKB)
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Alt. Names/Synonyms: AA536663; Degenerative spermatocyte homolog 1; degenerative spermatocyte homolog 1 (Drosophila); Degs; Degs1; delta(4)-desaturase, sphingolipid 1; Des; Des1; dihydroceramide desaturase; Dihydroceramide desaturase-1; Mde; Mdes; OTTMUSP00000024135; Sphingolipid delta(4)-desaturase DES1
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Gene Symbols: Degs1
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Molecular weight:
38,241 Da
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Basal Isoelectric point:
7.33
Predict pI for various phosphorylation states
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