CRK Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. Belongs to the CRK family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 17p13.3
Cellular Component:  actin cytoskeleton; cytoplasm; cytosol; membrane raft; nucleus; plasma membrane; protein-containing complex
Molecular Function:  cytoskeletal protein binding; ephrin receptor binding; insulin-like growth factor receptor binding; phosphotyrosine residue binding; protein binding; protein phosphorylated amino acid binding; protein self-association; protein tyrosine kinase binding; scaffold protein binding; SH2 domain binding; SH3 domain binding; SH3/SH2 adaptor activity
Biological Process:  activation of GTPase activity; activation of MAPKK activity; cell chemotaxis; cellular response to endothelin; cellular response to insulin-like growth factor stimulus; cellular response to nerve growth factor stimulus; cellular response to nitric oxide; cellular response to transforming growth factor beta stimulus; cerebellar neuron development; cerebral cortex development; cytokine-mediated signaling pathway; dendrite development; ephrin receptor signaling pathway; establishment of cell polarity; Fc-gamma receptor signaling pathway involved in phagocytosis; helper T cell diapedesis; hippocampus development; lipid metabolic process; negative regulation of cell motility; negative regulation of natural killer cell mediated cytotoxicity; negative regulation of wound healing; neuron migration; positive regulation of smooth muscle cell migration; positive regulation of substrate adhesion-dependent cell spreading; reelin-mediated signaling pathway; regulation of actin cytoskeleton organization; regulation of cell adhesion mediated by integrin; regulation of cell shape; regulation of dendrite development; regulation of GTPase activity; regulation of protein binding; regulation of Rac protein signal transduction; regulation of signal transduction; regulation of T cell migration; regulation of transcription by RNA polymerase II; response to cholecystokinin; response to hepatocyte growth factor; response to hydrogen peroxide; response to yeast; vascular endothelial growth factor receptor signaling pathway
Reference #:  P46108 (UniProtKB)
Alt. Names/Synonyms: Adapter molecule crk; avian sarcoma virus CT10 (v-crk) oncogene homolog; CRK; CRKII; Proto-oncogene c-Crk; v-crk avian sarcoma virus CT10 oncogene homolog; v-crk sarcoma virus CT10 oncogene homolog (avian)
Gene Symbols: CRK
Molecular weight: 33,831 Da
Basal Isoelectric point: 5.38  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  Insulin Receptor Signaling  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein