SACM1L Phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P). Has low activity towards PtdIns(3,5)P2. Detected in heart, brain, lung, liver, kidney, pancreas and testis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.-; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Phosphatase, lipid
Chromosomal Location of Human Ortholog: 9 F4|9 74.08 cM
Cellular Component:  AMPA glutamate receptor complex; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; integral component of endoplasmic reticulum membrane; integral component of membrane; membrane
Molecular Function:  hydrolase activity; phosphatase activity; phosphatidylinositol bisphosphate phosphatase activity; phosphatidylinositol-3-phosphatase activity; phosphatidylinositol-4-phosphate phosphatase activity; phosphoric ester hydrolase activity
Biological Process:  phosphatidylinositol dephosphorylation
Reference #:  Q9EP69 (UniProtKB)
Alt. Names/Synonyms: Kiaa0851; mKIAA0851; Phosphatidylinositide phosphatase SAC1; Phosphatidylinositol-3-phosphatase SAC1; Phosphatidylinositol-4-phosphate phosphatase; polyphosphatidylinositol phosphatase; Sac1; SAC1 (suppressor of actin mutations 1, homolog)-like (S. cerevisiae); SAC1 suppressor of actin mutations 1-like (yeast); Sac1p; Sacm1l; Suppressor of actin mutations 1-like protein
Gene Symbols: Sacm1l
Molecular weight: 66,944 Da
Basal Isoelectric point: 6.85  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene