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LACTB2
Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability. Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.-.-.-; Hydrolase; Mitochondrial |
| Chromosomal Location of mouse Ortholog: 1|1 A3 |
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Cellular Component:
mitochondrial matrix
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Molecular Function:
endonuclease activity; endoribonuclease activity; hydrolase activity; metal ion binding; nuclease activity; RNA binding; single-stranded RNA binding; zinc ion binding
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Biological Process:
RNA phosphodiester bond hydrolysis, endonucleolytic
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Reference #:
Q99KR3
(UniProtKB)
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Alt. Names/Synonyms: Beta-lactamase-like protein 2; Cgi-8; Cgi-83; E430032H21Rik; Endoribonuclease LACTB2; LACB2; lactamase, beta 2; Lactb2; MGC7674; OTTMUSP00000024094
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Gene Symbols: Lactb2
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Molecular weight:
32,754 Da
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Basal Isoelectric point:
5.89
Predict pI for various phosphorylation states
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