LACTB2 Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability. Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. Note: This description may include information from UniProtKB.
Protein type: EC 3.-.-.-; Hydrolase; Mitochondrial
Chromosomal Location of mouse Ortholog: 1|1 A3
Cellular Component:  mitochondrial matrix
Molecular Function:  endonuclease activity; endoribonuclease activity; hydrolase activity; metal ion binding; nuclease activity; RNA binding; single-stranded RNA binding; zinc ion binding
Biological Process:  RNA phosphodiester bond hydrolysis, endonucleolytic
Reference #:  Q99KR3 (UniProtKB)
Alt. Names/Synonyms: Beta-lactamase-like protein 2; Cgi-8; Cgi-83; E430032H21Rik; Endoribonuclease LACTB2; LACB2; lactamase, beta 2; Lactb2; MGC7674; OTTMUSP00000024094
Gene Symbols: Lactb2
Molecular weight: 32,754 Da
Basal Isoelectric point: 5.89  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene