LEMD2
Involved in nuclear structure organization. Required for maintaining the integrity of the nuclear envelope. Required for embryonic development and is involved in regulation of several signaling pathways such as MAPK and AKT. Required for myoblast differentiation involving regulation of ERK signaling. Ubiquitously expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Nuclear envelope |
Chromosomal Location of human Ortholog: 6p21.31 |
Cellular Component:
endoplasmic reticulum; membrane; nuclear envelope; nuclear inner membrane; nuclear membrane; spindle
|
Molecular Function:
protein binding
|
Biological Process:
heart formation; negative regulation of MAPK cascade; negative regulation of protein kinase B signaling; neurogenesis; nuclear envelope organization; protein localization to chromatin; skeletal muscle cell differentiation
|
Disease: Cataract 46, Juvenile-onset; Marbach-rustad Progeroid Syndrome
|
Reference #:
Q8NC56
(UniProtKB)
|
Alt. Names/Synonyms: CTRCT42; dJ482C21.1; hLEM2; lamina-associated polypeptide-emerin-MAN1 domain containing 2; LEM domain containing 2; LEM domain nuclear envelope protein 2; LEM domain-containing protein 2; LEM2; LEMD2; NET25
|
Gene Symbols: LEMD2
|
Molecular weight:
56,975 Da
|
Basal Isoelectric point:
9.16
Predict pI for various phosphorylation states
|