LEMD2 Involved in nuclear structure organization. Required for maintaining the integrity of the nuclear envelope. Required for embryonic development and is involved in regulation of several signaling pathways such as MAPK and AKT. Required for myoblast differentiation involving regulation of ERK signaling. Ubiquitously expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Nuclear envelope
Chromosomal Location of human Ortholog: 6p21.31
Cellular Component:  endoplasmic reticulum; membrane; nuclear envelope; nuclear inner membrane; nuclear membrane; spindle
Molecular Function:  protein binding
Biological Process:  heart formation; negative regulation of MAPK cascade; negative regulation of protein kinase B signaling; neurogenesis; nuclear envelope organization; protein localization to chromatin; skeletal muscle cell differentiation
Disease: Cataract 46, Juvenile-onset; Marbach-rustad Progeroid Syndrome
Reference #:  Q8NC56 (UniProtKB)
Alt. Names/Synonyms: CTRCT42; dJ482C21.1; hLEM2; lamina-associated polypeptide-emerin-MAN1 domain containing 2; LEM domain containing 2; LEM domain nuclear envelope protein 2; LEM domain-containing protein 2; LEM2; LEMD2; NET25
Gene Symbols: LEMD2
Molecular weight: 56,975 Da
Basal Isoelectric point: 9.16  Predict pI for various phosphorylation states
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LEMD2

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein