LEMD2 Involved in nuclear structure organization. Required for maintaining the integrity of the nuclear envelope. Required for embryonic development and is involved in regulation of several signaling pathways such as MAPK and AKT. Required for myoblast differentiation involving regulation of ERK signaling. Ubiquitously expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Nuclear envelope
Chromosomal Location of mouse Ortholog: 17|17 A3.3
Cellular Component:  integral component of membrane; integral component of nuclear inner membrane; membrane; nuclear inner membrane; nuclear membrane; nucleus
Biological Process:  heart formation; negative regulation of BMP signaling pathway; negative regulation of MAPK cascade; negative regulation of protein kinase B signaling; neurogenesis; nuclear envelope organization; protein localization to chromatin; regulation of intracellular signal transduction; skeletal muscle cell differentiation
Reference #:  Q6DVA0 (UniProtKB)
Alt. Names/Synonyms: BC026588; Lem; LEM domain containing 2; LEM domain-containing protein 2; Lem2; Lemd2; MGC37253; NET2; NET25; nuclear envelope constituent; Nuclear envelope transmembrane protein 25
Gene Symbols: Lemd2
Molecular weight: 57,507 Da
Basal Isoelectric point: 9.18  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene