SAPCD2 Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions. Negatively regulates the mitotic apical cortex localization of GPSM2. Involved also in positive regulation of cell proliferation and tumor cell growth. Expressed in 5-month-old fetal tissues, including stomach, intestine, colon, liver, brain, lung, heart, spleen and kidney (PubMed:17525738). Undetectable in non-cancerous adult tissues (PubMed:17525738). Expressed in many primary gastric carcinoma, but almost not in adjacent normal mucosa (PubMed:17525738). Expressed preferentially in M and G1 phases, compared to S and G2 phases (PubMed:17525738). Expression is up-regulated in hepatocellular carcinoma (HCC) and colorectal cancer (CRC) tissues (at protein level) (PubMed:23704824). Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of human Ortholog: 9q34.3
Cellular Component:  apical cortex; apical junction complex; apical plasma membrane; bicellular tight junction; cytosol; nucleolus; nucleoplasm
Molecular Function:  protein binding
Biological Process:  establishment of mitotic spindle orientation; negative regulation of protein localization to cell cortex; positive regulation of cell population proliferation; regulation of establishment of planar polarity; symmetric cell division
Reference #:  Q86UD0 (UniProtKB)
Alt. Names/Synonyms: 2010317E24Rik; C9orf140; chromosome 9 open reading frame 140; CI140; p42.3; Protein C9orf140; SAPC2; SAPCD2; suppressor APC domain containing 2; Suppressor APC domain-containing protein 2; TS/MDEP; Tumor specificity and mitosis phase-dependent expression protein
Gene Symbols: SAPCD2
Molecular weight: 42,637 Da
Basal Isoelectric point: 9.14  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein