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SAPCD2
Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions. Negatively regulates the mitotic apical cortex localization of GPSM2. Involved also in positive regulation of cell proliferation and tumor cell growth. Expressed in 5-month-old fetal tissues, including stomach, intestine, colon, liver, brain, lung, heart, spleen and kidney (PubMed:17525738). Undetectable in non-cancerous adult tissues (PubMed:17525738). Expressed in many primary gastric carcinoma, but almost not in adjacent normal mucosa (PubMed:17525738). Expressed preferentially in M and G1 phases, compared to S and G2 phases (PubMed:17525738). Expression is up-regulated in hepatocellular carcinoma (HCC) and colorectal cancer (CRC) tissues (at protein level) (PubMed:23704824). Note: This description may include information from UniProtKB.
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| Protein type: Unknown function |
| Chromosomal Location of human Ortholog: 9q34.3 |
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Cellular Component:
apical cortex; apical junction complex; apical plasma membrane; bicellular tight junction; cytosol; nucleolus; nucleoplasm
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Molecular Function:
protein binding
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Biological Process:
establishment of mitotic spindle orientation; negative regulation of protein localization to cell cortex; positive regulation of cell population proliferation; regulation of establishment of planar polarity; symmetric cell division
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Reference #:
Q86UD0
(UniProtKB)
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Alt. Names/Synonyms: 2010317E24Rik; C9orf140; chromosome 9 open reading frame 140; CI140; p42.3; Protein C9orf140; SAPC2; SAPCD2; suppressor APC domain containing 2; Suppressor APC domain-containing protein 2; TS/MDEP; Tumor specificity and mitosis phase-dependent expression protein
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Gene Symbols: SAPCD2
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Molecular weight:
42,637 Da
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Basal Isoelectric point:
9.14
Predict pI for various phosphorylation states
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