SHRM Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers. Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays. Belongs to the shroom family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 5 E2|5 47.29 cM
Cellular Component:  adherens junction; apical junction complex; apical part of cell; apical plasma membrane; cell junction; cortical actin cytoskeleton; cytoplasm; cytoskeleton; microtubule
Molecular Function:  actin binding; actin filament binding
Biological Process:  actin cytoskeleton organization; actin filament organization; cell morphogenesis; columnar/cuboidal epithelial cell development; epithelial cell development; multicellular organism development; neural tube closure; pattern specification process; regulation of cell shape
Reference #:  Q9QXN0 (UniProtKB)
Alt. Names/Synonyms: AL022960; D5Ertd287; D5Ertd287e; Kiaa1481; Protein Shroom3; Shr; Shrm; Shrm3; shroom family member 3; Shroom3
Gene Symbols: Shroom3
Molecular weight: 214,888 Da
Basal Isoelectric point: 8.21  Predict pI for various phosphorylation states
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SHRM

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene