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TMEM48
Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane. Belongs to the NDC1 family. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Nucleoporin |
| Chromosomal Location of Human Ortholog: 4|4 C7 |
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Cellular Component:
actin cytoskeleton; cytoplasm; integral component of membrane; membrane; nuclear membrane; nuclear pore; nuclear pore transmembrane ring; nucleus; plasma membrane
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Molecular Function:
structural constituent of nuclear pore
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Biological Process:
mRNA transport; nuclear pore complex assembly; nuclear pore distribution; nuclear pore organization; protein transport; spermatogenesis; synapsis
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Reference #:
Q8VCB1
(UniProtKB)
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Alt. Names/Synonyms: 2810475A17Rik; AI450313; Ndc1; NDC1 transmembrane nucleoporin; Nucleoporin NDC1; OTTMUSP00000009215; sks; Tmem48; Transmembrane protein 48
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Gene Symbols: Tmem48
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Molecular weight:
75,409 Da
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Basal Isoelectric point:
9.09
Predict pI for various phosphorylation states
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