TMEM48 Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane. Belongs to the NDC1 family. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Nucleoporin
Chromosomal Location of mouse Ortholog: 4|4 C7
Cellular Component:  actin cytoskeleton; cytoplasm; membrane; nuclear envelope; nuclear membrane; nuclear pore; nuclear pore transmembrane ring; nucleus; plasma membrane
Molecular Function:  protein-macromolecule adaptor activity; structural constituent of nuclear pore
Biological Process:  homologous chromosome pairing at meiosis; mRNA transport; nuclear pore complex assembly; nuclear pore localization; nuclear pore organization; nucleocytoplasmic transport; protein transport; spermatogenesis
Reference #:  Q8VCB1 (UniProtKB)
Alt. Names/Synonyms: 2810475A17Rik; AI450313; Ndc1; NDC1 transmembrane nucleoporin; Nucleoporin NDC1; OTTMUSP00000009215; sks; Tmem48; Transmembrane protein 48
Gene Symbols: Tmem48
Molecular weight: 75,409 Da
Basal Isoelectric point: 9.09  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene