NOS1AP Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 1q23.3
Cellular Component:  cytosol; glutamatergic synapse; mitochondrion; nucleus; perinuclear region of cytoplasm; sarcolemma; sarcoplasmic reticulum membrane; Z disc
Molecular Function:  nitric-oxide synthase binding; protein binding
Biological Process:  positive regulation of delayed rectifier potassium channel activity; positive regulation of gene expression; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric oxide mediated signal transduction; positive regulation of nitric-oxide synthase activity; positive regulation of peptidyl-cysteine S-nitrosylation; positive regulation of potassium ion transmembrane transport; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization; postsynaptic actin cytoskeleton organization; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; regulation of cardiac muscle cell action potential; regulation of heart rate by chemical signal; regulation of high voltage-gated calcium channel activity; regulation of nitric oxide biosynthetic process; regulation of nitric-oxide synthase activity; regulation of ventricular cardiac muscle cell membrane repolarization
Disease: Qt Interval, Variation In
Reference #:  O75052 (UniProtKB)
Alt. Names/Synonyms: 6330408P19Rik; C-terminal PDZ domain ligand of neuronal nitric oxide synthase (CAPON); C-terminal PDZ ligand of neuronal nitric oxide synthase protein; CAPON; Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein; KIAA0464; ligand of neuronal nitric oxide synthase with carboxyl-terminal PDZ domain; MGC138500; nitric oxide synthase 1 (neuronal) adaptor protein; Nitric oxide synthase 1 adaptor protein; NOS1AP
Gene Symbols: NOS1AP
Molecular weight: 56,150 Da
Basal Isoelectric point: 5.89  Predict pI for various phosphorylation states
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NOS1AP

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein