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SNX33
Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes. Belongs to the sorting nexin family. Detected in heart and pancreas. Note: This description may include information from UniProtKB.
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| Protein type: Unknown function |
| Chromosomal Location of mouse Ortholog: 9|9 B |
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Cellular Component:
cytoplasm; cytoplasmic vesicle; cytosol; membrane; plasma membrane
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Molecular Function:
identical protein binding; phosphatidylinositol binding
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Biological Process:
cell cycle; cell division; cleavage furrow formation; endocytosis; endosomal transport; endosome organization; intracellular protein transport; macropinocytosis; mitotic cell cycle; mitotic cytokinesis; negative regulation of endocytosis; negative regulation of protein localization to cell surface; plasma membrane tubulation; positive regulation of membrane protein ectodomain proteolysis; positive regulation of protein localization to cell surface; protein import; protein transport
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Reference #:
Q4VAA7
(UniProtKB)
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Alt. Names/Synonyms: E130307J07Rik; SH3 and PX domain containing 3; SH3 and PX domain-containing protein 3; Sh3p; Sh3px3; Snx33; sorting nexin 33; Sorting nexin-33
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Gene Symbols: Snx33
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Molecular weight:
65,315 Da
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Basal Isoelectric point:
6.3
Predict pI for various phosphorylation states
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