RBBP6 E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; EC 6.3.2.-; EC; Ligase; Nucleolus; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 7|7 F2
Cellular Component:  chromosome; cytoplasm; cytoskeleton; nuclear speck; nucleus; protein-containing complex
Molecular Function:  metal ion binding; nucleic acid binding; protein kinase binding; transferase activity; ubiquitin protein ligase activity; ubiquitin-protein transferase activity; zinc ion binding
Biological Process:  cellular response to DNA damage stimulus; DNA replication; embryonic organ development; in utero embryonic development; mRNA processing; multicellular organism growth; protein ubiquitination; regulation of DNA replication; somite development; ubiquitin-dependent protein catabolic process
Reference #:  P97868 (UniProtKB)
Alt. Names/Synonyms: 4933422O15Rik; AI316869; BB233631; C030034J04Rik; C77662; E3 ubiquitin-protein ligase RBBP6; MGC32263; OTTMUSP00000030772; P2P-R; P2pr; p53-associated cellular protein of testis; Pact; Proliferation potential-related protein; Protein P2P-R; Rbbp6; retinoblastoma binding protein 6; Retinoblastoma-binding protein 6
Gene Symbols: Rbbp6
Molecular weight: 199,587 Da
Basal Isoelectric point: 9.65  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene