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RBBP6
E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth. Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication. Highly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney, liver and lung. Overexpressed in esophageal cancer. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; EC 6.3.2.-; EC 6.3.2.19; Ligase; Nucleolus; Ubiquitin conjugating system; Ubiquitin ligase |
| Chromosomal Location of mouse Ortholog: 7|7 F2 |
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Cellular Component:
centrosome; chromosome; cytoplasm; cytoskeleton; nuclear speck; nucleus; protein-containing complex
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Molecular Function:
metal ion binding; nucleic acid binding; protein kinase binding; transferase activity; ubiquitin protein ligase activity; ubiquitin-protein transferase activity; zinc ion binding
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Biological Process:
DNA damage response; DNA replication; embryonic organ development; in utero embryonic development; mRNA processing; multicellular organism growth; protein ubiquitination; regulation of DNA replication; somite development; ubiquitin-dependent protein catabolic process
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Reference #:
P97868
(UniProtKB)
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Alt. Names/Synonyms: 4933422O15Rik; AI316869; BB233631; C030034J04Rik; C77662; E3 ubiquitin-protein ligase RBBP6; MGC32263; OTTMUSP00000030772; P2P-R; P2pr; p53-associated cellular protein of testis; Pact; Proliferation potential-related protein; Protein P2P-R; Rbbp6; retinoblastoma binding protein 6; retinoblastoma binding protein 6, ubiquitin ligase; Retinoblastoma-binding protein 6; RING-type E3 ubiquitin transferase RBBP6
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Gene Symbols: Rbbp6
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Molecular weight:
199,587 Da
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Basal Isoelectric point:
9.65
Predict pI for various phosphorylation states
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