CCL6 Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23. Belongs to the intercrine beta (chemokine CC) family. High levels in adult lung, liver, skeletal muscle and pancreas. Moderate levels in fetal liver, adult bone marrow and placenta. The short form is the major species and the longer form was detected only in very low abundance. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are found in high levels in synovial fluids from rheumatoid patients. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 17q12
Cellular Component:  cell; extracellular region
Molecular Function:  CCR1 chemokine receptor binding; chemokine activity; heparin binding
Biological Process:  cell-cell signaling; cellular calcium ion homeostasis; chemotaxis; G protein-coupled receptor signaling pathway; immune response; monocyte chemotaxis; negative regulation of C-C chemokine binding; negative regulation of cell proliferation; regulation of signaling receptor activity; signal transduction
Reference #:  P55773 (UniProtKB)
Alt. Names/Synonyms: C-C motif chemokine 23; C-C motif chemokine ligand 23; C6 beta-chemokine; CCL23; CCL23(19-99); CCL23(22-99); CCL23(27-99); CCL23(30-99); CCL6; chemokine (C-C motif) ligand 23; CK-beta-8; CKB-8; Ckb-8-1; CKb8; hmrp-2a; Macrophage inflammatory protein 3; MIP-3; MIP3; MPIF-1; MPIF1; Myeloid progenitor inhibitory factor 1; SCYA23; small inducible cytokine subfamily A (Cys-Cys), member 23; Small-inducible cytokine A23
Gene Symbols: CCL23
Molecular weight: 13,411 Da
Basal Isoelectric point: 9.21  Predict pI for various phosphorylation states
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CCL6

Protein Structure Not Found.


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