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SELENBP1
Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport. Belongs to the selenium-binding protein family. Widely expressed. Highly expressed in liver, lung, colon, prostate, kidney and pancreas. In brain, present both in neurons and glia (at protein level). Down-regulated in lung adenocarcinoma, colorectal carcinoma and ovarian cancer. Two-fold up-regulated in brain and blood from schizophrenia patients. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Chromosomal Location of human Ortholog: 1q21.3 |
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Cellular Component:
cytosol; fibrillar center; membrane; nucleolus
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Molecular Function:
methanethiol oxidase activity; protein binding; selenium binding
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Biological Process:
protein transport
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Disease: Extraoral Halitosis Due To Methanethiol Oxidase Deficiency
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Reference #:
Q13228
(UniProtKB)
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Alt. Names/Synonyms: 56 kDa selenium-binding protein; EHMTO; epididymis secretory sperm binding protein Li 134P; FLJ13813; HEL-S-134P; hSBP; hSP56; LPSB; Methanethiol oxidase; MTO; SBP; SBP1; SBP56; SELENBP1; selenium binding protein 1; Selenium-binding protein 1; SP56
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Gene Symbols: SELENBP1
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Molecular weight:
52,391 Da
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Basal Isoelectric point:
5.93
Predict pI for various phosphorylation states
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