SELENBP1 Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport. Belongs to the selenium-binding protein family. Widely expressed. Highly expressed in liver, lung, colon, prostate, kidney and pancreas. In brain, present both in neurons and glia (at protein level). Down-regulated in lung adenocarcinoma, colorectal carcinoma and ovarian cancer. Two-fold up-regulated in brain and blood from schizophrenia patients. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 1q21.3
Cellular Component:  cytosol; fibrillar center; membrane; nucleolus
Molecular Function:  methanethiol oxidase activity; protein binding; selenium binding
Biological Process:  oxidation-reduction process; protein transport
Disease: Extraoral Halitosis Due To Methanethiol Oxidase Deficiency
Reference #:  Q13228 (UniProtKB)
Alt. Names/Synonyms: 56 kDa selenium-binding protein; EHMTO; epididymis secretory sperm binding protein Li 134P; FLJ13813; HEL-S-134P; hSBP; hSP56; LPSB; Methanethiol oxidase; MTO; SBP; SBP1; SBP56; SELENBP1; selenium binding protein 1; Selenium-binding protein 1; SP56
Gene Symbols: SELENBP1
Molecular weight: 52,391 Da
Basal Isoelectric point: 5.93  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein