DNAHC12 Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly. Belongs to the dynein heavy chain family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3p14.3
Cellular Component:  cilium; cytoplasm; dynein complex; microtubule
Molecular Function:  ATP binding; microtubule motor activity
Biological Process:  microtubule-based movement
Reference #:  Q6ZR08 (UniProtKB)
Alt. Names/Synonyms: Axonemal beta dynein heavy chain 12; axonemal dynein heavy chain 12-like protein; axonemal dynein heavy chain 7-like protein; axonemal dynein heavy chain isotype3; Ciliary dynein heavy chain 12; DHC3; DLP12; DLP3; DNAH12; DNAH12L; DNAH7L; DNAHC12; DNAHC3; DNHD2; DYH12; dynein axonemal heavy chain 12; Dynein heavy chain 12, axonemal; Dynein heavy chain 7-like, axonemal; dynein heavy chain domain 2; Dynein heavy chain domain-containing protein 2; dynein heavy domain 2; dynein, axonemal, heavy chain 12; dynein, axonemal, heavy chain 12-like; dynein, axonemal, heavy chain 7-like; dynein, axonemal, heavy polypeptide 12; Dynein, heavy chain-5; FLJ40427; FLJ44290; HDHC3; HL-19; HL19
Gene Symbols: DNAH12
Molecular weight: 356,942 Da
Basal Isoelectric point: 5.85  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  Ensembl Protein