DNAHC12
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly. Belongs to the dynein heavy chain family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Motility/polarity/chemotaxis |
Chromosomal Location of human Ortholog: 3p14.3 |
Cellular Component:
axonemal dynein complex; microtubule
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Molecular Function:
ATP binding; dynein intermediate chain binding; dynein light intermediate chain binding; minus-end-directed microtubule motor activity
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Biological Process:
microtubule-based movement
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Reference #:
Q6ZR08
(UniProtKB)
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Alt. Names/Synonyms: Axonemal beta dynein heavy chain 12; axonemal dynein heavy chain 12-like protein; axonemal dynein heavy chain 7-like protein; axonemal dynein heavy chain isotype3; Ciliary dynein heavy chain 12; DHC3; DLP12; DLP3; DNAH12; DNAH12L; DNAH7L; DNAHC12; DNAHC3; DNHD2; DYH12; Dynein axonemal heavy chain 12; Dynein heavy chain 12, axonemal; Dynein heavy chain 7-like, axonemal; dynein heavy chain domain 2; Dynein heavy chain domain-containing protein 2; dynein heavy domain 2; dynein, axonemal, heavy chain 12; dynein, axonemal, heavy chain 12-like; dynein, axonemal, heavy chain 7-like; dynein, axonemal, heavy polypeptide 12; Dynein, heavy chain-5; FLJ40427; FLJ44290; HDHC3; HL-19; HL19
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Gene Symbols: DNAH12
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Molecular weight:
356,942 Da
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Basal Isoelectric point:
5.85
Predict pI for various phosphorylation states
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