ZDHHC20 Catalyzes palmitoylation of Cys residues on target proteins. Catalyzes palmitoylation of Cys residues in the cytoplasmic C-terminus of EGFR, and modulates the duration of EGFR signaling by modulating palmitoylation-dependent EGFR internalization and degradation. Has a preference for acyl-CoA with C16 fatty acid chains. Can also utilize acyl-CoA with C14 and C18 fatty acid chains. Belongs to the DHHC palmitoyltransferase family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Membrane protein, multi-pass; Transferase
Chromosomal Location of human Ortholog: 13q12.11
Cellular Component:  integral component of Golgi membrane; perinuclear region of cytoplasm; plasma membrane
Molecular Function:  palmitoyltransferase activity; protein-cysteine S-palmitoyltransferase activity; zinc ion binding
Biological Process:  peptidyl-L-cysteine S-palmitoylation; protein palmitoylation
Reference #:  Q5W0Z9 (UniProtKB)
Alt. Names/Synonyms: 4933421L13Rik; DHHC-20; DHHC-containing protein 20; DHHC20; FLJ25952; MGC126005; Palmitoyltransferase ZDHHC20; Probable palmitoyltransferase ZDHHC20; ZDH20; ZDHHC20; Zinc finger DHHC domain-containing protein 20; zinc finger DHHC-type containing 20; zinc finger DHHC-type palmitoyltransferase 20; zinc finger, DHHC domain containing 20; zinc finger, DHHC-type containing 20
Gene Symbols: ZDHHC20
Molecular weight: 42,278 Da
Basal Isoelectric point: 7.87  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB