WDFY1 Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines. Note: This description may include information from UniProtKB.
Chromosomal Location of human Ortholog: 2q36.1
Cellular Component:  cytosol; early endosome; nucleus
Molecular Function:  1-phosphatidylinositol binding; protein binding; zinc ion binding
Biological Process:  positive regulation of toll-like receptor 3 signaling pathway; positive regulation of toll-like receptor 4 signaling pathway
Reference #:  Q8IWB7 (UniProtKB)
Alt. Names/Synonyms: FENS-1; FENS1; FYVE domain-containing protein localized to endosomes 1; KIAA1435; Phosphoinositide-binding protein 1; phosphoinositide-binding protein SR1; WD repeat and FYVE domain containing 1; WD repeat and FYVE domain-containing protein 1; WD40 and FYVE domain containing 1; WD40- and FYVE domain-containing protein 1; WDF1; WDFY1; ZFYVE17; Zinc finger FYVE domain-containing protein 17
Gene Symbols: WDFY1
Molecular weight: 46,324 Da
Basal Isoelectric point: 6.99  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene