SP140 Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails. High levels in spleen and peripheral blood leukocytes, much lower levels in tonsils, thymus, prostate, ovary, small intestine, and colon (PubMed:8695863, PubMed:8910577.) Very low levels in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas (PubMed:8910577). Not detected in brain, liver and muscle (PubMed:8695863). 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of human Ortholog: 2q37.1
Cellular Component:  fibrillar center; mitochondrion; nucleus; PML body
Molecular Function:  DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; protein binding
Biological Process:  defense response; regulation of transcription by RNA polymerase II
Reference #:  Q13342 (UniProtKB)
Alt. Names/Synonyms: LY10; Lymphoid-restricted homolog of Sp100; lymphoid-specific SP100 homolog; LYSP100; LYSP100-A; LYSP100-B; MGC126440; Nuclear autoantigen Sp-140; Nuclear body protein SP140; SP140; SP140 nuclear body protein; Speckled 140 kDa
Gene Symbols: SP140
Molecular weight: 98,223 Da
Basal Isoelectric point: 5.21  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene