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CIP29
Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Low expression in spleen, liver, pancreas, testis, thymus, heart, and kidney. Increased levels are seen in hepatocellular carcinoma and pancreatic adenocarcinoma. Note: This description may include information from UniProtKB.
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| Protein type: RNA-binding |
| Chromosomal Location of human Ortholog: 12q13.2 |
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Cellular Component:
cytoplasmic ribonucleoprotein granule; nuclear speck; nucleoplasm; nucleus; transcription export complex
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Molecular Function:
chromatin binding; DNA binding; protein binding
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Biological Process:
mRNA export from nucleus; negative regulation of transcription by RNA polymerase II; poly(A)+ mRNA export from nucleus; regulation of translation
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Reference #:
P82979
(UniProtKB)
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Alt. Names/Synonyms: CIP29; cytokine induced protein 29 kDa; Cytokine-induced protein of 29 kDa; HCC1; hepatocellular carcinoma 1; HSPC316; MGC14726; Nuclear protein Hcc-1; proliferation associated cytokine-inducible protein CIP29; Proliferation-associated cytokine-inducible protein CIP29; SAP domain containing ribonucleoprotein; SAP domain-containing ribonucleoprotein; SARNP; THO1
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Gene Symbols: SARNP
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Molecular weight:
23,671 Da
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Basal Isoelectric point:
6.1
Predict pI for various phosphorylation states
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