TMSB4X Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase. Belongs to the thymosin beta family. Expressed in several hemopoietic cell lines and lymphoid malignant cells. Decreased levels in myeloma cells. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: Xp22.2
Cellular Component:  cytoplasm; cytoskeleton; cytosol; extracellular region; nucleus; platelet alpha granule lumen
Molecular Function:  actin monomer binding; enzyme binding; protein binding
Biological Process:  actin filament organization; cytoplasmic sequestering of NF-kappaB; negative regulation of interleukin-8 secretion; negative regulation of NF-kappaB transcription factor activity; negative regulation of NIK/NF-kappaB signaling; negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding; platelet degranulation; positive regulation of ATP biosynthetic process; positive regulation of blood vessel endothelial cell migration; positive regulation of endothelial cell chemotaxis; positive regulation of proton-transporting ATP synthase activity, rotational mechanism; regulation of inflammatory response; regulation of NIK/NF-kappaB signaling; sequestering of actin monomers; tumor necrosis factor-mediated signaling pathway
Reference #:  P62328 (UniProtKB)
Alt. Names/Synonyms: Fx; Hematopoietic system regulatory peptide; prothymosin beta-4; PTMB4; Seraspenide; T beta-4; TB4X; THYB4; thymosin beta 4 X-linked; thymosin beta 4, X-linked; Thymosin beta-4; thymosin, beta 4; thymosin, beta 4, X chromosome; TMSB4; TMSB4X; TYB4
Gene Symbols: TMSB4X
Molecular weight: 5,053 Da
Basal Isoelectric point: 5.02  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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