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TMSB4X
Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase. Belongs to the thymosin beta family. Expressed in several hemopoietic cell lines and lymphoid malignant cells. Decreased levels in myeloma cells. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: Xp22.2 |
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Cellular Component:
cytoplasm; cytoskeleton; cytosol; extracellular region; nucleus; platelet alpha granule lumen
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Molecular Function:
actin monomer binding; enzyme binding; protein binding
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Biological Process:
actin filament organization; cytoplasmic sequestering of NF-kappaB; negative regulation of interleukin-8 production; negative regulation of NF-kappaB transcription factor activity; negative regulation of NIK/NF-kappaB signaling; negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding; positive regulation of ATP biosynthetic process; positive regulation of blood vessel endothelial cell migration; positive regulation of endothelial cell chemotaxis; positive regulation of proton-transporting ATP synthase activity, rotational mechanism; regulation of cell migration; regulation of inflammatory response; regulation of NIK/NF-kappaB signaling; sequestering of actin monomers; tumor necrosis factor-mediated signaling pathway
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Reference #:
P62328
(UniProtKB)
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Alt. Names/Synonyms: Fx; Hematopoietic system regulatory peptide; prothymosin beta-4; PTMB4; Seraspenide; T beta-4; TB4X; THYB4; thymosin beta 4 X-linked; thymosin beta 4, X-linked; Thymosin beta-4; thymosin, beta 4; thymosin, beta 4, X chromosome; TMSB4; TMSB4X; TYB4
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Gene Symbols: TMSB4X
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Molecular weight:
5,053 Da
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Basal Isoelectric point:
5.02
Predict pI for various phosphorylation states
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