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PRIC285
Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA. Belongs to the DNA2/NAM7 helicase family. Expressed in various tissues including heart, pancreas, skeletal muscle, colon, spleen, liver, kidney, lung, peripheral blood and placenta. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: C2H2-type zinc finger protein; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor |
| Chromosomal Location of mouse Ortholog: 2|2 H4 |
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Cellular Component:
cytosol; nucleoplasm; nucleus; P granule
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Molecular Function:
ATP binding; DNA binding; helicase activity; hydrolase activity; metal ion binding; nuclear receptor coactivator activity; nucleotide binding; RNA binding; RNA nuclease activity
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Biological Process:
positive regulation of transcription by RNA polymerase II; regulatory ncRNA-mediated post-transcriptional gene silencing
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Reference #:
E9QAM5
(UniProtKB)
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Alt. Names/Synonyms: BC006779; BC006779 protein; cDNA sequence BC006779; helicase with zinc finger 2, transcriptional coactivator; Helicase with zinc finger domain 2; HELZ2; MGC63178; mKIAA1769; mPDIP1; PDIP1; peroxisomal proliferator-activated receptor A interacting complex 285; PPAR gamma-DNA-binding domain interacting protein1; PPAR-gamma DBD-interacting protein 1; PPAR-gamma DNA-binding domain-interacting protein 1; Pric285
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Gene Symbols: Helz2
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Molecular weight:
331,563 Da
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Basal Isoelectric point:
8.41
Predict pI for various phosphorylation states
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