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PICK1
Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Cell development/differentiation; Ligand, receptor tyrosine kinase |
| Chromosomal Location of mouse Ortholog: 15|15 E1 |
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Cellular Component:
cytoplasm; cytoskeleton; cytosol; dendrite; dendritic spine; glutamatergic synapse; Golgi apparatus; membrane; mitochondrion; neuron projection; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; postsynaptic early endosome; postsynaptic endocytic zone; postsynaptic specialization; presynaptic membrane; protein-containing complex; synapse; synaptic vesicle; trans-Golgi network membrane
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Molecular Function:
actin binding; actin filament binding; Arp2/3 complex binding; cytoskeletal protein binding; G protein-coupled glutamate receptor binding; G protein-coupled receptor binding; identical protein binding; ionotropic glutamate receptor binding; membrane curvature sensor activity; metal ion binding; phospholipid binding; protein binding; protein domain specific binding; protein kinase C binding; signaling receptor binding; SNAP receptor activity
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Biological Process:
cellular response to decreased oxygen levels; cellular response to glucose starvation; dendritic spine maintenance; dendritic spine organization; glial cell development; intracellular protein transport; intracellular signal transduction; long-term synaptic depression; monoamine transport; negative regulation of Arp2/3 complex-mediated actin nucleation; negative regulation of gene expression; positive regulation of receptor internalization; protein kinase C-activating G protein-coupled receptor signaling pathway; protein phosphorylation; protein targeting; receptor clustering; regulation of Arp2/3 complex-mediated actin nucleation; regulation of insulin secretion; regulation of kainate selective glutamate receptor activity; regulation of postsynaptic neurotransmitter receptor internalization; regulation of synapse structure or activity
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Reference #:
Q62083
(UniProtKB)
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Alt. Names/Synonyms: Pick1; Prk; PRKCA-binding protein; Prkcabp; Protein interacting with C kinase 1; protein kinase C, alpha binding protein; Protein kinase C-alpha-binding protein; protein that interacts with C kinase 1
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Gene Symbols: Pick1
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Molecular weight:
46,597 Da
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Basal Isoelectric point:
5.34
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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