|
TR-alpha
Isoform Alpha-1: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Isoform Alpha-2: Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action. Belongs to the nuclear hormone receptor family. NR1 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: DNA-binding; Nuclear receptor; Transcription factor |
|
Cellular Component:
cytosol; nucleus; RNA polymerase II transcription regulator complex
|
|
Molecular Function:
chromatin DNA binding; nuclear receptor activity; protein binding; protein domain specific binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding; TBP-class protein binding; thyroid hormone binding; zinc ion binding
|
|
Biological Process:
cartilage condensation; cell differentiation; erythrocyte differentiation; female courtship behavior; learning or memory; mRNA transcription by RNA polymerase II; negative regulation of RNA polymerase II transcription preinitiation complex assembly; negative regulation of transcription by RNA polymerase II; ossification; positive regulation of cold-induced thermogenesis; positive regulation of female receptivity; positive regulation of thyroid hormone mediated signaling pathway; positive regulation of transcription by RNA polymerase II; regulation of heart contraction; regulation of lipid catabolic process; regulation of myeloid cell apoptotic process; response to cold; retinoic acid receptor signaling pathway; thyroid gland development; thyroid hormone mediated signaling pathway
|
|
Reference #:
NP_990644
(RefSeq)
|
|
Alt. Names/Synonyms: c-erb-A protein; nuclear receptor subfamily 1 group A member 1; THRA; thyroid hormone receptor alpha; thyroid hormone receptor beta; thyroid hormone receptor, alpha; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian); TR-alpha
|
|
Gene Symbols: THRA
|
|
Molecular weight:
46,757 Da
|
|
Basal Isoelectric point:
7.46
Predict pI for various phosphorylation states
|
