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UBXN2B
Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity. Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Belongs to the NSFL1C family. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Endoplasmic reticulum |
| Chromosomal Location of human Ortholog: 8q12.1 |
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Cellular Component:
cytosol; endoplasmic reticulum; Golgi apparatus; nucleus; spindle pole centrosome
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Molecular Function:
protein binding; ubiquitin binding
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Biological Process:
autophagosome assembly; establishment of mitotic spindle orientation; Golgi organization; membrane fusion; negative regulation of protein localization to centrosome; nuclear membrane reassembly; positive regulation of mitotic centrosome separation; proteasome-mediated ubiquitin-dependent protein catabolic process
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Reference #:
Q14CS0
(UniProtKB)
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Alt. Names/Synonyms: NSFL1 cofactor p37; p37; p97 cofactor p37; UBX domain protein 2B; UBX domain-containing protein 2B; UBX2B; UBXN2B
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Gene Symbols: UBXN2B
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Molecular weight:
37,077 Da
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Basal Isoelectric point:
5.49
Predict pI for various phosphorylation states
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