MTSS1L Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation. May function in actin bundling. Belongs to the MTSS family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component:  cortical actin cytoskeleton; lamellipodium; ruffle membrane
Molecular Function:  actin monomer binding; GTPase activator activity; phosphatidylinositol-4,5-bisphosphate binding; Rac GTPase binding
Biological Process:  activation of GTPase activity; cellular response to platelet-derived growth factor stimulus; lamellipodium organization; plasma membrane organization; ruffle assembly
Reference #:  Q765P7 (UniProtKB)
Alt. Names/Synonyms: ABBA; ABBA-1; ABBA1; actin-bundling protein with BAIAP2 homology; Actin-bundling with BAIAP2 homology protein 1; metastasis suppressor 1-like; MTSS I-BAR domain containing 2; MTSS1-like protein; MTSS1L; MTSS1L, I-BAR domain containing; MTSS2; MTSSL; Protein MTSS 2
Gene Symbols: MTSS1L
Molecular weight: 79,929 Da
Basal Isoelectric point: 7.18  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene