LRRC8C Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. Belongs to the LRRC8 family. Expressed at highest levels in skeletal muscle, and at moderate levels in heart, lung and peripheral blood leukocytes. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of human Ortholog: 1p22.2
Cellular Component:  cytoplasm; endoplasmic reticulum membrane; ion channel complex; plasma membrane
Molecular Function:  protein binding; volume-sensitive anion channel activity
Biological Process:  anion transmembrane transport; aspartate transmembrane transport; cellular response to osmotic stress; cyclic-GMP-AMP transmembrane import across plasma membrane; fat cell differentiation; inorganic anion transport; protein hexamerization; taurine transport
Reference #:  Q8TDW0 (UniProtKB)
Alt. Names/Synonyms: AD158; DKFZp586J1119; factor for adipocyte differentiation 158; FAD158; hypothetical protein AD158; leucine rich repeat containing 8 family member C; leucine rich repeat containing 8 family, member C; leucine rich repeat containing 8 VRAC subunit C; leucine rich repeat containing 8C; Leucine-rich repeat-containing protein 8C; LRC8C; LRRC8C; MGC138551; Protein AD158; Volume-regulated anion channel subunit LRRC8C
Gene Symbols: LRRC8C
Molecular weight: 92,450 Da
Basal Isoelectric point: 7.54  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein