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LRRC8C
Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. Belongs to the LRRC8 family. Expressed at highest levels in skeletal muscle, and at moderate levels in heart, lung and peripheral blood leukocytes. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of Human Ortholog: 1p22.2 |
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Cellular Component:
cytoplasm; endoplasmic reticulum membrane; integral component of plasma membrane; ion channel complex; plasma membrane
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Molecular Function:
protein binding; volume-sensitive anion channel activity
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Biological Process:
anion transmembrane transport; aspartate transmembrane transport; cell volume homeostasis; cellular response to osmotic stress; fat cell differentiation; inorganic anion transport; protein hexamerization; taurine transport; transmembrane transport
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Reference #:
Q8TDW0
(UniProtKB)
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Alt. Names/Synonyms: AD158; DKFZp586J1119; factor for adipocyte differentiation 158; FAD158; leucine rich repeat containing 8 family, member C; leucine rich repeat containing 8C; Leucine-rich repeat-containing protein 8C; LRC8C; LRRC8C; MGC138551; Protein AD158; Volume-regulated anion channel subunit LRRC8C
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Gene Symbols: LRRC8C
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Molecular weight:
92,450 Da
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Basal Isoelectric point:
7.54
Predict pI for various phosphorylation states
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