SPIRE1 Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage. Belongs to the spire family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of human Ortholog: 18p11.21
Cellular Component:  cell cortex; cleavage furrow; cytoplasmic vesicle membrane; cytoskeleton; cytosol; mitochondrial outer membrane; nucleoplasm; perinuclear region of cytoplasm
Molecular Function:  actin binding; protein binding
Biological Process:  actin cytoskeleton organization; actin filament network formation; actin filament polymerization; actin nucleation; cleavage furrow formation; establishment of meiotic spindle localization; formin-nucleated actin cable assembly; Golgi vesicle transport; innate immune response; intracellular transport; polar body extrusion after meiotic divisions; positive regulation of double-strand break repair; positive regulation of mitochondrial fission; protein transport; vesicle-mediated transport
Reference #:  Q08AE8 (UniProtKB)
Alt. Names/Synonyms: KIAA1135; MGC150621; MGC150622; Protein spire homolog 1; Spir-1; SPIR1; spire actin nucleation factor 1; spire family actin nucleation factor 1; spire homolog 1; spire homolog 1 (Drosophila); spire type actin nucleation factor 1; SPIRE1
Gene Symbols: SPIRE1
Molecular weight: 85,544 Da
Basal Isoelectric point: 8.89  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein