PLEKHG6 Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis. Highest expression in the placenta. Low levels in small intestine, lung, liver, kidney, thymus and heart. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rac/Rho
Chromosomal Location of human Ortholog: 12p13.31
Cellular Component:  cell junction; centrosome; cleavage furrow; cytosol; microvillus; spindle pole
Molecular Function:  GTPase activator activity; guanyl-nucleotide exchange factor activity; protein binding
Biological Process:  regulation of catalytic activity; regulation of small GTPase mediated signal transduction
Reference #:  Q3KR16 (UniProtKB)
Alt. Names/Synonyms: FLJ10665; MGC126315; MGC126353; MGC126354; MyoGEF; myosin II interacting GEF; myosin interacting guanine nucleotide exchange factor; Myosin-interacting guanine nucleotide exchange factor; PH domain-containing family G member 6; PKHG6; pleckstrin homology and RhoGEF domain containing G6; pleckstrin homology domain containing, family G (with RhoGef domain) member 6; Pleckstrin homology domain-containing family G member 6; PLEKHG6
Gene Symbols: PLEKHG6
Molecular weight: 88,960 Da
Basal Isoelectric point: 6.63  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein