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PLCL2
May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Phospholipase |
| Chromosomal Location of human Ortholog: 3p24.3 |
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Cellular Component:
cytoplasm
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Molecular Function:
GABA receptor binding; inositol 1,4,5 trisphosphate binding; phosphatidylinositol phospholipase C activity; protein binding
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Biological Process:
B cell proliferation involved in immune response; B-1a B cell differentiation; gamma-aminobutyric acid signaling pathway; intracellular signal transduction; lipid metabolic process; negative regulation of B cell receptor signaling pathway; negative regulation of cold-induced thermogenesis; positive regulation of receptor binding; regulation of synaptic transmission, GABAergic
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Reference #:
Q9UPR0
(UniProtKB)
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Alt. Names/Synonyms: FLJ13484; Inactive phospholipase C-like protein 2; KIAA1092; phospholipase C like 2; phospholipase C, epsilon 2; Phospholipase C-epsilon-2; Phospholipase C-L2; phospholipase C-like 2; PLC-epsilon-2; PLC-L(2); PLC-L2; PLCE2; PLCL2
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Gene Symbols: PLCL2
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Molecular weight:
125,866 Da
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Basal Isoelectric point:
6.47
Predict pI for various phosphorylation states
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CST Pathways:
ErbB/HER Signaling
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