SEC31A Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. Belongs to the WD repeat SEC31 family. Abundantly and ubiquitously expressed. 10 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Oncoprotein; Vesicle
Chromosomal Location of Human Ortholog: 4q21.22
Cellular Component:  COPII vesicle coat; COPII-coated ER to Golgi transport vesicle; cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum exit site; endoplasmic reticulum membrane; ER to Golgi transport vesicle membrane; Golgi membrane; intracellular membrane-bounded organelle; perinuclear region of cytoplasm; vesicle coat
Molecular Function:  calcium-dependent protein binding; protein binding
Biological Process:  antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of peptide antigen via MHC class I; cargo loading into COPII-coated vesicle; COPII vesicle coating; ER to Golgi vesicle-mediated transport; IRE1-mediated unfolded protein response; response to calcium ion
Disease: Neurodevelopmental Disorder With Spastic Quadriplegia, Optic Atrophy, Seizures, And Structural Brain Anomalies
Reference #:  O94979 (UniProtKB)
Alt. Names/Synonyms: ABP125; ABP130; DKFZp686N07171; HSPC275; HSPC334; KIAA0905; MGC90305; NEDSOSB; Protein transport protein Sec31A; protein-transport protein SEC31; SC31A; SEC31 homolog A (S. cerevisiae); SEC31 homolog A, COPII coat complex component; SEC31 homolog A, COPII coating complex component; SEC31-like 1; SEC31-like protein 1; SEC31-related protein A; SEC31A; SEC31L1; Web1-like protein; yeast Sec31p homolog
Gene Symbols: SEC31A
Molecular weight: 133,015 Da
Basal Isoelectric point: 6.43  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein