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FAT4
Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation. Widely expressed. Expressed in fetal brain, infant brain, brain tumor and colorectal cancer. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell adhesion; Membrane protein, integral |
| Chromosomal Location of Human Ortholog: 4q28.1 |
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Cellular Component:
apical part of cell; integral component of membrane; plasma membrane
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Molecular Function:
calcium ion binding; protein binding
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Biological Process:
branching involved in ureteric bud morphogenesis; cerebral cortex development; condensed mesenchymal cell proliferation; digestive tract development; fibroblast growth factor receptor signaling pathway; heart morphogenesis; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; hippo signaling; homophilic cell adhesion via plasma membrane adhesion molecules; inner ear receptor cell stereocilium organization; neurogenesis; Notch signaling pathway; ossification involved in bone maturation; plasma membrane organization; regulation of metanephric nephron tubule epithelial cell differentiation
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Disease: Hennekam Lymphangiectasia-lymphedema Syndrome 2; Van Maldergem Syndrome 2
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Reference #:
Q6V0I7
(UniProtKB)
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Alt. Names/Synonyms: Cadherin family member 14; cadherin-related family member 11; CDHF14; CDHR11; FAT atypical cadherin 4; FAT tumor suppressor homolog 4; FAT tumor suppressor homolog 4 (Drosophila); FAT-J; fat-like cadherin FATJ; Fat-like cadherin protein FAT-J; FAT4; FATJ; FLJ23056; FLJ77878; hFat4; HKLLS2; NBLA00548; Protocadherin Fat 4; putative protein product of Nbla00548; VMLDS2
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Gene Symbols: FAT4
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Molecular weight:
542,687 Da
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Basal Isoelectric point:
4.77
Predict pI for various phosphorylation states
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CST Pathways:
Hippo Signaling
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