FAT4 Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation. Widely expressed. Expressed in fetal brain, infant brain, brain tumor and colorectal cancer. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4q28.1
Cellular Component:  apical part of cell; integral component of membrane; plasma membrane
Molecular Function:  calcium ion binding; protein binding
Biological Process:  branching involved in ureteric bud morphogenesis; cerebral cortex development; condensed mesenchymal cell proliferation; digestive tract development; fibroblast growth factor receptor signaling pathway; heart morphogenesis; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; hippo signaling; homophilic cell adhesion via plasma membrane adhesion molecules; inner ear receptor cell stereocilium organization; neurogenesis; Notch signaling pathway; ossification involved in bone maturation; plasma membrane organization; regulation of metanephric nephron tubule epithelial cell differentiation
Disease: Hennekam Lymphangiectasia-lymphedema Syndrome 2; Van Maldergem Syndrome 2
Reference #:  Q6V0I7 (UniProtKB)
Alt. Names/Synonyms: Cadherin family member 14; cadherin-related family member 11; CDHF14; CDHR11; FAT atypical cadherin 4; FAT tumor suppressor homolog 4; FAT tumor suppressor homolog 4 (Drosophila); FAT-J; fat-like cadherin FATJ; Fat-like cadherin protein FAT-J; FAT4; FATJ; FLJ23056; FLJ77878; hFat4; HKLLS2; NBLA00548; Protocadherin Fat 4; putative protein product of Nbla00548; VMLDS2
Gene Symbols: FAT4
Molecular weight: 542,687 Da
Basal Isoelectric point: 4.77  Predict pI for various phosphorylation states
CST Pathways:  Hippo Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene