DOK4 DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells. Belongs to the DOK family. Type B subfamily. Widely expressed. High expression in skeletal muscle, heart, kidney and liver. Weaker expression in spleen, lung and small intestine, brain, heart and. Expressed in both resting and activated peripheral blood T-cells. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Cell development/differentiation
Chromosomal Location of human Ortholog: 16q21
Cellular Component:  cytosol
Molecular Function:  protein binding
Biological Process:  axon guidance
Reference #:  Q8TEW6 (UniProtKB)
Alt. Names/Synonyms: Docking protein 4; DOK4; Downstream of tyrosine kinase 4; FLJ10488; Insulin receptor substrate 5; IRS-5; IRS5
Gene Symbols: DOK4
Molecular weight: 37,028 Da
Basal Isoelectric point: 8.37  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene