IPO3 Seems to function in nuclear protein import as nuclear transport receptor. In vitro, mediates the nuclear import of splicing factor SR proteins RBM4, SFRS1 and SFRS2, by recognizing phosphorylated RS domains. Expressed in skeletal muscle. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Karyopherin; Nuclear export; Nuclear import; Receptor, misc.
Chromosomal Location of human Ortholog: 7q32.1
Cellular Component:  intracellular membrane-bounded organelle; nucleus
Molecular Function:  identical protein binding; protein binding; signaling receptor activity
Biological Process:  protein import into nucleus
Disease: Muscular Dystrophy, Limb-girdle, Type 1f
Reference #:  Q9Y5L0 (UniProtKB)
Alt. Names/Synonyms: Imp12; importin 12; Importin-12; IPO12; IPO3; LGMD1F; LGMDD2; limb girdle muscular dystrophy 1F (autosomal dominant); MTR10A; TNPO3; transportin 3; Transportin-3; Transportin-SR; TRN-SR; TRN-SR2; TRNSR
Gene Symbols: TNPO3
Molecular weight: 104,204 Da
Basal Isoelectric point: 5.35  Predict pI for various phosphorylation states
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IPO3

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein