KIF3A Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitement of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motor
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component:  axon cytoplasm; centriole; centrosome; ciliary tip; cilium; cytosol; kinesin II complex; microtubule cytoskeleton
Molecular Function:  ATP binding; ATP-dependent microtubule motor activity, plus-end-directed; protein binding; protein phosphatase binding; Rab GTPase binding; spectrin binding
Biological Process:  antigen processing and presentation of exogenous peptide antigen via MHC class II; centriole-centriole cohesion; cilium assembly; intraciliary transport involved in cilium assembly; microtubule anchoring at centrosome; microtubule-based movement; organelle organization; plus-end-directed vesicle transport along microtubule; protein localization to cell junction; protein transport; retrograde vesicle-mediated transport, Golgi to ER
Reference #:  Q9Y496 (UniProtKB)
Alt. Names/Synonyms: KIF3; KIF3A; kinesin family member 3A; kinesin family protein 3A; Kinesin-like protein KIF3A; Microtubule plus end-directed kinesin motor 3A
Gene Symbols: KIF3A
Molecular weight: 80,041 Da
Basal Isoelectric point: 6.16  Predict pI for various phosphorylation states
CST Pathways:  Hedgehog Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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KIF3A

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene