VPS24 Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor. Isoform 2 prevents stress-mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells. Belongs to the SNF7 family. Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of human Ortholog: 2p11.2
Cellular Component:  cytoplasmic vesicle; cytosol; ESCRT III complex; late endosome; late endosome membrane; plasma membrane
Molecular Function:  phosphatidylcholine binding; protein binding; protein homodimerization activity; ubiquitin-specific protease binding
Biological Process:  apoptotic process; autophagosome maturation; endosomal transport; macroautophagy; midbody abscission; multivesicular body assembly; multivesicular body sorting pathway; multivesicular body-lysosome fusion; negative regulation of viral release from host cell; positive regulation of viral release from host cell; protein heterooligomerization; protein polymerization; regulation of centrosome duplication; regulation of early endosome to late endosome transport; regulation of viral process; viral budding via host ESCRT complex; viral life cycle
Reference #:  Q9Y3E7 (UniProtKB)
Alt. Names/Synonyms: 25.1 protein; CGI-149; CGI149; Charged multivesicular body protein 3; CHMP family, member 3; CHMP3; Chromatin-modifying protein 3; hVps24; NEDF; Neuroendocrine differentiation factor; vacuolar protein sorting 24 homolog; vacuolar protein sorting 24 homolog (S. cerevisiae); Vacuolar protein sorting-associated protein 24; VPS24
Gene Symbols: CHMP3
Molecular weight: 25,073 Da
Basal Isoelectric point: 5.1  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein