VPS24 Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor. Isoform 2 prevents stress-mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells. Belongs to the SNF7 family. Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of human Ortholog: 2p11.2
Cellular Component:  amphisome membrane; autophagosome membrane; cytoplasmic vesicle; cytosol; early endosome; ESCRT III complex; kinetochore; kinetochore microtubule; late endosome; lysosomal membrane; midbody; multivesicular body; multivesicular body membrane; nuclear pore; plasma membrane
Molecular Function:  molecular function inhibitor activity; phosphatidylcholine binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; ubiquitin-specific protease binding
Biological Process:  apoptotic process; autophagosome maturation; autophagy; endosome transport via multivesicular body sorting pathway; late endosome to lysosome transport; late endosome to vacuole transport; macroautophagy; membrane fission; midbody abscission; mitotic metaphase plate congression; multivesicular body assembly; multivesicular body sorting pathway; multivesicular body-lysosome fusion; nuclear membrane reassembly; nucleus organization; plasma membrane repair; positive regulation of cytokinesis; protein polymerization; protein transport; regulation of centrosome duplication; regulation of early endosome to late endosome transport; regulation of endosome size; regulation of exosomal secretion; regulation of mitotic spindle assembly; suppression of viral release by host; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; vesicle fusion with vacuole; viral budding from plasma membrane; viral budding via host ESCRT complex; viral release from host cell
Reference #:  Q9Y3E7 (UniProtKB)
Alt. Names/Synonyms: 25.1 protein; CGI-149; CGI149; Charged multivesicular body protein 3; CHMP family, member 3; CHMP3; Chromatin-modifying protein 3; hVps24; NEDF; Neuroendocrine differentiation factor; vacuolar protein sorting 24 homolog; vacuolar protein sorting 24 homolog (S. cerevisiae); Vacuolar protein sorting-associated protein 24; VPS24
Gene Symbols: CHMP3
Molecular weight: 25,073 Da
Basal Isoelectric point: 5.1  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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