USP20 Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the peptidase C19 family. USP20/USP33 subfamily. Note: This description may include information from UniProtKB.
Protein type: EC; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease
Chromosomal Location of human Ortholog: 9q34.11
Cellular Component:  centrosome; cytoplasm; cytosol; endoplasmic reticulum; perinuclear region of cytoplasm
Molecular Function:  cysteine-type deubiquitinase activity; cysteine-type endopeptidase activity; G protein-coupled receptor binding; protein binding; zinc ion binding
Biological Process:  antiviral innate immune response; endocytosis; negative regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of autophagy; protein deubiquitination; protein K48-linked deubiquitination; protein K63-linked deubiquitination; regulation of G protein-coupled receptor signaling pathway; ubiquitin-dependent protein catabolic process
Reference #:  Q9Y2K6 (UniProtKB)
Alt. Names/Synonyms: Deubiquitinating enzyme 20; hVDU2; KIAA1003; LSFR3A; pVHL-interacting deubiquitinating enzyme 2; Ubiquitin carboxyl-terminal hydrolase 20; ubiquitin specific peptidase 20; ubiquitin specific protease 20; Ubiquitin thioesterase 20; ubiquitin thiolesterase 20; Ubiquitin-specific-processing protease 20; UBP20; USP20; VDU2; VHL-interacting deubiquitinating enzyme 2
Gene Symbols: USP20
Molecular weight: 102,003 Da
Basal Isoelectric point: 5.75  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein