SLC24A2 Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 9p22.1-p21.3
Cellular Component:  plasma membrane
Molecular Function:  calcium, potassium:sodium antiporter activity; protein dimerization activity; symporter activity
Biological Process:  ion transmembrane transport; ion transport; learning; memory; potassium ion transport; response to stimulus; sodium ion transmembrane transport; visual perception
Reference #:  Q9UI40 (UniProtKB)
Alt. Names/Synonyms: Na(+)/K(+)/Ca(2+)-exchange protein 2; NCKX2; Retinal cone Na-Ca+K exchanger; SLC24A2; Sodium/potassium/calcium exchanger 2; solute carrier family 24 (sodium/potassium/calcium exchanger), member 2; Solute carrier family 24 member 2
Gene Symbols: SLC24A2
Molecular weight: 73,664 Da
Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein