MAIR-I Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6. Belongs to the CD300 family. Expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Immunoglobulin superfamily; Membrane protein, integral
Chromosomal Location of human Ortholog: 17q25.1
Cellular Component:  ficolin-1-rich granule membrane; membrane; plasma membrane; tertiary granule membrane
Molecular Function:  phosphatidylethanolamine binding; phosphatidylserine binding; protein binding; signaling receptor activity; transmembrane signaling receptor activity
Biological Process:  cell adhesion; immune system process; negative regulation of activation of Janus kinase activity; negative regulation of B cell proliferation; negative regulation of B cell receptor signaling pathway; negative regulation of eosinophil activation; negative regulation of eosinophil migration; negative regulation of fibroblast proliferation; negative regulation of MAP kinase activity; negative regulation of mast cell activation involved in immune response; negative regulation of mast cell degranulation; negative regulation of MyD88-dependent toll-like receptor signaling pathway; negative regulation of neutrophil activation; negative regulation of NK T cell activation; negative regulation of phagocytosis, engulfment; positive regulation of phosphoprotein phosphatase activity; regulation of T cell receptor signaling pathway
Reference #:  Q9UGN4 (UniProtKB)
Alt. Names/Synonyms: CD300 antigen-like family member A; CD300A; CD300a antigen; CD300a molecule; CLM-8; CLM8; CMRF-35-H9; CMRF-35H; CMRF35-H; CMRF35-H9; CMRF35-like molecule 8; CMRF35H; CMRF35H leukocyte immunoglobulin-like receptor; CMRF35H9; IGSF12; Immunoglobulin superfamily member 12; Inhibitory receptor protein 60; IRC1; IRC1/IRC2; IRC2; IRp60; leukocyte membrane antigen; MAIR-I; NK inhibitory receptor
Gene Symbols: CD300A
Molecular weight: 33,201 Da
Basal Isoelectric point: 5.35  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein