RNMT Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC. Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.1.1.56; Methyltransferase; RNA processing
Chromosomal Location of Human Ortholog: 18p11.21
Cellular Component:  fibrillar center; mRNA cap binding complex; mRNA cap methyltransferase complex; nucleoplasm; nucleus; receptor complex
Molecular Function:  mRNA (guanine-N7-)-methyltransferase activity; protein binding; RNA binding
Biological Process:  7-methylguanosine mRNA capping; cellular response to leukemia inhibitory factor; RNA 5'-cap (guanine-N7)-methylation; transcription by RNA polymerase II
Reference #:  O43148 (UniProtKB)
Alt. Names/Synonyms: cm1p; CMT1; CMT1c; DKFZp686H1252; hcm1p; hCMT1; hCMT1c; hMet; KIAA0398; MCES; MET; mRNA (guanine-7-)methyltransferase; mRNA (guanine-N(7)-)-methyltransferase; mRNA cap guanine-N7 methyltransferase; mRNA cap methyltransferase; RG7MT1; RNA (guanine-7-) methyltransferase; RNA guanine-7 methyltransferase; RNMT
Gene Symbols: RNMT
Molecular weight: 54,844 Da
Basal Isoelectric point: 6.29  Predict pI for various phosphorylation states
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RNMT

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB