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RNMT
Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC. Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.1.1.56; Methyltransferase; RNA processing |
| Chromosomal Location of Human Ortholog: 18p11.21 |
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Cellular Component:
fibrillar center; mRNA cap binding complex; mRNA cap methyltransferase complex; nucleoplasm; nucleus; receptor complex
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Molecular Function:
mRNA (guanine-N7-)-methyltransferase activity; protein binding; RNA binding
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Biological Process:
7-methylguanosine mRNA capping; cellular response to leukemia inhibitory factor; RNA 5'-cap (guanine-N7)-methylation; transcription by RNA polymerase II
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Reference #:
O43148
(UniProtKB)
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Alt. Names/Synonyms: cm1p; CMT1; CMT1c; DKFZp686H1252; hcm1p; hCMT1; hCMT1c; hMet; KIAA0398; MCES; MET; mRNA (guanine-7-)methyltransferase; mRNA (guanine-N(7)-)-methyltransferase; mRNA cap guanine-N7 methyltransferase; mRNA cap methyltransferase; RG7MT1; RNA (guanine-7-) methyltransferase; RNA guanine-7 methyltransferase; RNMT
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Gene Symbols: RNMT
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Molecular weight:
54,844 Da
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Basal Isoelectric point:
6.29
Predict pI for various phosphorylation states
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