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CHRAC1
Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1. Expressed in all tissues tested, including, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding |
| Chromosomal Location of human Ortholog: 8q24.3 |
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Cellular Component:
CHRAC; epsilon DNA polymerase complex; nucleus; pericentric heterochromatin
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Molecular Function:
DNA binding; DNA-directed DNA polymerase activity; protein binding; protein heterodimerization activity
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Biological Process:
chromatin remodeling; DNA biosynthetic process; DNA-templated DNA replication; nucleosome assembly; regulation of DNA replication
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Reference #:
Q9NRG0
(UniProtKB)
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Alt. Names/Synonyms: CHARC1; CHARC15; CHRAC-1; CHRAC-15; CHRAC1; CHRAC15; CHRC1; chromatin accessibility complex 1; Chromatin accessibility complex 15 kDa protein; Chromatin accessibility complex protein 1; chromatin accessibility complex subunit 1; DNA polymerase epsilon subunit p15; histone-fold protein CHRAC15; HuCHRAC15; YCL1
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Gene Symbols: CHRAC1
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Molecular weight:
14,711 Da
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Basal Isoelectric point:
4.99
Predict pI for various phosphorylation states
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