Kv7.5 Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. As the native M-channel, the potassium channel composed of KCNQ3 and KCNQ5 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1. Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.5/KCNQ5 sub-subfamily. Strongly expressed in brain and skeletal muscle. In brain, expressed in cerebral cortex, occipital pole, frontal lobe and temporal lobe. Lower levels in hippocampus and putamen. Low to undetectable levels in medulla, cerebellum and thalamus. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 6q13
Cellular Component:  clathrin coat; integral component of plasma membrane; plasma membrane; voltage-gated potassium channel complex
Molecular Function:  protein binding; voltage-gated potassium channel activity
Biological Process:  potassium ion transmembrane transport; regulation of ion transmembrane transport
Disease: Mental Retardation, Autosomal Dominant 46
Reference #:  Q9NR82 (UniProtKB)
Alt. Names/Synonyms: KCNQ5; KQT-like 5; Kv7.5; MRD46; potassium channel protein; Potassium channel subunit alpha KvLQT5; potassium channel, voltage gated KQT-like subfamily Q, member 5; Potassium voltage-gated channel subfamily KQT member 5; potassium voltage-gated channel subfamily Q member 5; potassium voltage-gated channel, KQT-like subfamily, member 5; Voltage-gated potassium channel subunit Kv7.5
Gene Symbols: KCNQ5
Molecular weight: 102,179 Da
Basal Isoelectric point: 9.55  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein